ONE-D Protocol for Depression: Accelerated TMS Treatment
Optimized Neuroplastogen Enhanced Depression (ONE-D) Protocol is now available at NeoPsych by Dr. Thomas Hughes. Looking for a faster alternative to traditional depression treatment? NeoPsych proudly offers the ONE-D Protocol, a new approach that combines accelerated TMS therapy with medications that enhance neuroplasticity, delivering symptom relief from depression in a single day of treatment.
What is the ONE- D Protocol?
The ONE-D Protocol is a one-day, accelerated neuromodulation treatment designed to deliver fast, effective relief for individuals struggling with depression. It combines three powerful components:
1. intermittent Theta Burst Stimulation (iTBS)
2. Neuroplasticity-enhancing medications
3. A highly structured, same-day treatment schedule consisting of 20 TMS sessions.
The ONE-D Protocol is a form of transcranial magnetic stimulation (TMS) that delivers short, high-frequency bursts of magnetic pulses to targeted areas of the brain associated with mood regulation. These sessions are significantly faster than traditional rTMS, typically lasting only 3 to 10 minutes each. Standard TMS treatments last 20 to 40 mins.
Comparison to Other TMS Protocols
Developed in response to the growing demand for faster and more accessible mental health care, the ONE-D Protocol offers mental health benefits in a condensed time frame, making it ideal for high-functioning professionals, parents, or individuals who are unable to commit to traditional five-day-per-week treatment schedules. This treatment option is not FDA approved. Please view the video on this page to learn more about the research associated with the protocol.
Other Protocol Options:
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Neuroplasticity Stimulants
In addition to the neuromodulation component, the ONE-D Protocol includes medications that enhance neuroplasticity—specifically D-Cycloserine and Vyvanse. These medications are carefully timed and dosed to prime the brain for treatment, increasing its responsiveness to stimulation and supporting the long-term formation of new neural pathways associated with mood improvement.
Who Is It For?
The ONE-D protocol is ideal for:
- Individuals unable to commit to daily TMS sessions over several weeks
- Patients seeking non-medication-based depression treatment
The one day protocol is a compelling option for busy professionals, parents, students, and others with limited time for conventional treatment plans.
Neopsych offers convenient hours for people in this category to take advantage of the new advancements in TMS research
How the ONE-D Protocol Works
Over the past decade, researchers in neuromodulation and psychiatry have continually pushed the boundaries of what’s possible with transcranial magnetic stimulation (TMS). Traditionally, patients underwent TMS treatments five days a week for six to seven weeks—a significant time commitment that many found difficult to maintain. However, new data and technological advancements have reshaped this model. Evidence now shows that positive outcomes can be achieved with accelerated TMS protocols, condensing what used to take over a month. The ONE-D Protocol is the latest option being offered in the TMS community.
By combining iTBS with neuroplasticity-enhancing medications, the protocol enables the brain to respond more efficiently to stimulation while reducing the overall treatment burden on the patient. This not only leads to faster results but also makes care more affordable and accessible to a wider range of individuals.
These medications are being used off-label, which is common in advanced psychiatric treatments. That means they’re being safely used for purposes beyond their original FDA approval, based on growing clinical research.
D-cycloserine is a supplement being used as an adjunct to many other conditions, such as OCD and anxiety. Vyvanse is a well-tolerated medication that is used to address ADHD and treatment-resistant depression. iTBS has also been studied extensively, and found to be very effective when used for accelerated protocols.
Clinical Outcomes: What Patients Can Expect After ONE-D Treatment
The clinical results from the ONE-D Protocol are promising. In a cohort of patients who received the full-day protocol, over 90% reported a significant improvement in depressive symptoms by week 12 following treatment. Even more impressively, more than 74.2% of patients reported near-complete or total remission of depression symptoms.
It is important to note that symptom relief is not typically immediate. While the treatment is completed in a single day, improvements tend to emerge gradually over the course of several weeks, as neural pathways continue to strengthen and adapt.
These results show that ONE-D Protocol can be an effective and time-efficient option for individuals seeking rapid relief from major depressive disorder, particularly those who have not responded to standard medications or prefer to avoid long-term pharmaceutical interventions.
Hamilton Depression Rating Scale
ONE-D Protocol Schedule
Patients follow a structured schedule beginning early in the morning and continuing until all 20 sessions are completed. The day typically looks like this:
- 6:00 AM – Administration of D-Cycloserine and Vyvanse
- 6:30 AM – Completion of depression and anxiety rating scales
- 7:00 AM to 11:30 AM – TMS treatments every 30 minutes, 10 sessions before lunch
- Afternoon – Remaining 10 sessions completed in the same pattern
This intensive schedule is designed to stimulate rapid neuroplastic changes that support improved mood regulation.
Ready to Take the Next Step?
If you’ve been struggling with depression or anxiety and want a faster, more effective option, the ONE-D Protocol may be right for you. Book your consultation today and find out if you’re a candidate for this breakthrough treatment.