Major depressive disorder affects emotional, cognitive, and physical functioning. While antidepressant medications and psychotherapy are effective for many individuals, a significant portion of patients do not achieve sufficient relief. For those with treatment-resistant depression, symptoms may persist despite multiple medication trials and ongoing therapy.
Transcranial magnetic stimulation has become an established, evidence-based option for patients seeking an alternative approach. In Los Angeles, TMS is increasingly utilized as part of comprehensive psychiatric care for individuals who value noninvasive treatment supported by clinical research. At NeoPsych, TMS is delivered with precision and oversight by Dr. Thomas Hughes.
This article reviews success rates, treatment structure, and what patients can realistically expect when pursuing TMS for depression.
HOW TMS TREATS DEPRESSION
TMS targets brain regions consistently implicated in depression, particularly the dorsolateral prefrontal cortex. Repeated magnetic stimulation influences neuronal activity and neuroplasticity, supporting improved communication within mood-regulating networks.
Multiple randomized controlled trials have demonstrated that TMS can produce clinically meaningful symptom reduction in patients who did not respond to antidepressant medications. A 2024 study in the Journal of Affective Disorders confirmed sustained benefit in treatment-resistant populations.
Unlike medications, TMS does not alter neurotransmitter levels systemically. Its localized mechanism allows patients to avoid many medication-related side effects.
SUCCESS RATES AND CLINICAL OUTCOMES
Success rates vary based on individual factors, including severity of depression, treatment history, and adherence to the protocol. Clinical studies indicate that a substantial percentage of patients experience symptom reduction, with some achieving remission.
A 2023 randomized trial published in Brain Stimulation reported that many responders maintained improvement for several months following treatment, particularly with appropriate psychiatric follow-up.
Dr. Hughes emphasizes that TMS is not an instant or guaranteed solution. Rather, it represents a statistically supported option for individuals who have exhausted conventional treatments.
NUMBER OF SESSIONS AND TREATMENT STRUCTURE
A standard TMS course typically involves five sessions per week for approximately six weeks. Each session lasts around 20 minutes, depending on the protocol used.
During the initial appointment, motor threshold testing establishes individualized stimulation parameters. Subsequent sessions build on this foundation, with adjustments made when clinically indicated.
Patients remain awake throughout treatment and can return to normal activities immediately afterward.
WHAT PATIENTS EXPERIENCE DURING TREATMENT
Most patients describe TMS as tolerable. The most common sensation is tapping on the scalp. Mild headache or scalp tenderness may occur early in treatment and usually resolves without intervention.
There is no post-treatment recovery period. This allows patients to continue working, attending school, or managing family responsibilities during the course of care.
Symptom improvement typically occurs gradually, often becoming noticeable after several weeks.
WHO IS A CANDIDATE FOR TMS
Ideal candidates are adults diagnosed with major depressive disorder who have not achieved adequate relief from antidepressant medications or psychotherapy. Patients who cannot tolerate medication side effects may also be considered.
Contraindications include seizure disorders and certain implanted devices. Candidacy is determined through a comprehensive psychiatric evaluation.
MOVING FORWARD WITH INFORMED CARE
For individuals in Los Angeles living with persistent depression, TMS offers a noninvasive, evidence-based treatment option guided by psychiatric expertise. When incorporated into a structured care plan, it may support improved mood, cognition, and daily functioning.
NeoPsych provides TMS therapy within a clinically rigorous, patient-centered environment. A consultation with Dr. Hughes allows patients to explore whether TMS is an appropriate next step based on their history and goals.